This study involves a relationship between butyltins concentrations and histopathological changes of the digestive gland in the equilateral venus, Gomphina veneriformis exposed to TBTCl of 0.4, 0.6 and 0.8 ${mu}g/L$ for 36 weeks. In the sediment, total butyltin (${sum}BT$) concentration was detected ND~7.54 (0.4 ${mu}g/L$), ND~9.76 (0.6 ${mu}g/L$), 1.22~13.13 ${mu}g/L$ (0.8 ${mu}g/L$), respectively. Especially, TBT level in 0.8 ${mu}g/L$ group was the highest for 36 weeks. In the soft tissue, total butyltin (${sum}BT$) concentration of the exposure group was 10.14~12.75 (control), 479.29~1,286.56 (0.4 ${mu}g/L$), 563.32~2,154.82 (0.6 ${mu}g/L$) and 1,317.70~2,132.60 ${mu}g/L$ (0.8 ${mu}g/L$), respectively. Ratio of TBT to ${sum}BT$ of the tissue of 0.8 ${mu}g/L$ kept the lowest level for 36 weeks. The ${sum}BT$ concentrations of sediment were correlated with ${sum}BT$ concentrations in the tissue. In the exposure groups, necrosis and atrophy of columnar epithelial cell and collapse of epithelial layer in the digestive tubule. And there was a reduction in stain affinity of basophilic cell. Such histological degenerations was more severe in digestive tubule of 0.8 ${mu}g/L$ group.