Recently, several DDP, DDO and COS-based block ciphers have been proposed for hardware implementations with low cost. However, most of them are vulnerable to related-keyt attacks. A 12-round block cipher SCOS-3 is desinged to eliminate the weakness of DDP, DDO and COS-based block ciphers. In this paper, we propose a related-key differential attack on an 11-round reduced SCOS-3. The attack on an 11-round reduced SCOS-3 requires $2^{58}$ related-key chosen plaintexts and $2^{117.54}$ 11-round reduced SCOS-3 encryptions. This work is the first known attack on SCOS-3. Therefore, SCOS-3 is still vulnerable to related-key attacks.