This paper was proposed to show the comprehensive review of laws and regulations on the musculoskeletal disorders (MSDs) that are being established and carried out in various countries. Ten countries including USA, Canada, Australia, Japan, and 6 European countries which were regarded as the leaders in the prevention of MSDs were selected for review. Comparative analysis were performed on the laws, regulations, and guidelines of MSDs among different countries. The purpose of this study was to investigate the status of the various efforts of the advanced countries concerning on preventing MSDs and suggest the improvement factors that might be introducible to Korean policies. Some recommendations were made to improve the appropriateness and efficiency of our MSDs prevention policies based on the comprehensive review and comparative analysis. It is expected that the results of this study would be used as valuable information when revising relevant legal system.