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Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus
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  • Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus
  • Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus
저자명
Lee. Young-Min,Gweon. Oh-Cheon,Seo. Yeong-Ju,Im. Ji-Eun,Kang. Min-Jung,Kim. Myo-Jeong,Kim. Jung-In
간행물명
Nutrition research and practice
권/호정보
2009년|3권 2호|pp.156-161 (6 pages)
발행정보
한국영양학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes. The antioxidant activity of garlic and aged black garlic was measured as the activity in scavenging free radicals by the trolox equivalent antioxidant capacity (TEAC) assay. Three week-old db/db mice were fed AIN-93G diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Hepatic levels of lipid peroxides and activities of antioxidant enzymes were measured. TEAC values of garlic and aged black garlic were $13.3{pm}0.5$ and $59.2{pm}0.8{mu}mol/g$ wet weight, respectively. Consumption of aged black garlic significantly decreased hepatic thiobarbituric acid reactive substances (TBARS) level compared with the garlic group which showed lower TBARS level than control group (p<0.05). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of garlic and aged black garlic group were significantly elevated compared to the control group. Catalase (CAT) activity of aged black garlic group was increased compared with the control group. These results show that aged black garlic exerts stronger antioxidant activity than garlic in vitro and in vivo, suggesting garlic and aged black garlic, to a greater extent, could be useful in preventing diabetic complications.