Purpose: This study was aimed to identify the health related quality of life(HRQoL) by job characteristics and its predictors in Korean adult women. Methods: This study used data from cross-sectional surveys conducted for the 2005 National Health and Nutrition Survey, which was performed by using a face-to-face interview method. The data were analyzed by ANOVA, t-test and multiple regression using the SPSS program. Demographic characteristics, subject health state, EQ-5D were included in the study instruments. Results: The mean HRQoL index in the subjects was $0.792{pm}0.102$. There were significant statistical differences on HRQoL among job characteristics. The health related quality of life of non-physical workers was the highest. The significant predictors of the HRQoL of all subjects were the subjective health status, the present health status compared to the previous year, education, age, marital status and income. The factors accounted for 22.1% of variance in the health related quality of life and the predictors of the HRQoL among job characteristics were different. Conclusion: These results may contribute to development of nursing strategy to improve female health related quality of life. The health related quality of life program for adult women by job characteristics is advised based on results of the study.