Strategies have to be employed in information systems security in order to build and operate systems for information systems security in effective and structured manner. It is also essential for the entire organization to participate for successful implementation of the strategies and making them work. Current researches on information systems security strategy in organizations, however, have mainly been focused on deployment and operation of countermeasures based on strategic thinking and decision. In consequence, it is lack of research on overall frame for containing consideration factors required for moving and leading the whole enterprise for the holistic security purpose. Therefore, this paper proposes a framework for use in establishment of organization-wide information systems security strategies based on the concept of grand strategy from the traditional strategy research and on the four dimensional features of it.