We have produced, characterized and compared different colloidal vehicles based on nanoemulsions. We also have investigated morphology and droplet distribution by means of electron microscope and photon correlation spectroscopy. Nanoemulsion systems characterized by different method on formulations have been obtained. Hydration power has been studied by means of a corneometer, measuring the skin electrical capacitance before and after the application of various type of skin lotions. It has been demonstrated that nanoemulsion with oil or fatty alcohol displayed a pronounced hydration power with respect to the solubilization system. In order to compare the smoothness of the skin after using skin lotion, we have measured the friction force. The skin lotions produced by nanoemulsion technique show improved smoothness of an atopic skin.