Objectives : This study is to investigate the effect of the sasang constitutional prescription with peeling and MTS on Acne patients. Methods : We treated 81 acne patients with sasang constitutional prescription with peeling and MTS. After treatments we compared the before and after photos, and estimated by Korean Acne Grading System. Results & Conclusions : 1. Patients were comprised of 59 females and 22 males. And there were 30 adolescent and 51 postadolescent acne patients. Out of 81 acne patients, there were many 41 postadolescent female acne patients. 2. Sasang constitutional distribution was comprised of 74 Soyangin, 5 Soeumin and 2 Taeeumin 3. Yangkyuksanhwa-tang(48.1%) and Yangdokbackho-tang(40.7%) were used much in 81 acne patients. 4. Before the treatment, 92.3% of Yangkyuksanhwa-tang group and 63.6% of Yangdokbackho-tang group had mild acne symptom and acne grade mean of Yangdokbackho-tang group was higher than another groups. 5. Peeling times mean of 81 acne patients was 2.54 times and MTS times mean was 4.57 times. Acne grade was improved when peeling times were higher. 6. Before the treatment, 81 acne patients were comprised of 81.5% mild symptom and 18.5% severe symptom patients and acne grade mean was 2.75. After the treatment. there were only mild symptom patients and acne grade mean was 1.04.