The identification of significant structural components under seismic loading through a probabilistic approach is of interest to many structural engineers. The First-Order Second Moment method can be used to achieve this goal by estimating uncertainty in the seismic demand of a structural system induced by the capacity uncertainties of each structural component. Significant structural components are those to which the seismic demand of the structure is more sensitive than it is to other ones. The developed procedure demonstrated by a ductile reinforced concrete frame shows that it is computationally effective and robust in terms of identifying significant structural components.