The number of vehicles applied diesel engine are rapidly rising for fuel economy. Accompanying this trend, application of an after-treatment system is strictly required as a result of reinforced emission regulation. The Diesel Particulate Filter (DPF) system is considered as the most efficient method to reduce particulate matter by car makers but also in retrofit market. In this paper we discussed the optimization of active regeneration timing by comparing the fuel consumption from back pressure caused by PM loading and from active regeneration. The effects of back pressure of DPFs during PM loading, active regeneration condition and engine emission(PM) on additional fuel consumption are experimentally investigated and the proper regeneration timings according to DPF systems and fuel loss for 160,000km are determined.