As part of an evaluation for an in-vessel severe accident management strategy, a coolant injection into the reactor vessel under depressurization of the reactor coolant system (RCS) has been evaluated in detail using the SCDAP/RELAP5 computer code. A high-pressure sequence of a small break loss of coolant accident (SBLOCA) has been analyzed in the Optimized Power Reactor (OPR) 1000. The SCDAP/RELAP5 results have shown that safety injection timing and capacity with RCS depressurization timing and capacity are very effective on the reactor vessel failure during a severe accident. Only one train operation of the high pressure safety injection (HPSI) for 30,000 seconds with RCS depressurization prevents failure of the reactor vessel. In this case, the operation of only the low pressure safety injection (LPSI) without a HPSI does not prevent failure of the reactor vessel.