The objective of this work was to investigate the mechanism of heat transfer in hot-pressing process for MDF manufacturing by reference study. Firstly, general heat transfer theory was studied. The numerical analysis of heat transfer in hot-pressing process was studied on temperature profile, moisture profile, physical properties between moisture and board. The mechanism of heat and moisture transfer inside of board was analyzed by conduction, convection, radiation and diffusion of bound water in wood cell walls. Especially, the change of core temperature as hot press time was important factor to setup hot-pressing schedule in MDF manufacturing.