A research was conducted about the Reynolds number effect on the projectile with an altitude change. The atmosphere conditions change in accordance with an altitude change. It effects the Reynolds number. To confirm how the phenomena affect the trajectory of the projectile, a computer program is designed with an altitude and a range considered. The MISSILE DATCOM which is based on the semi-empirical method was utilized to get aerodynamic coefficients. The result shows that the Reynolds number considerably changes as the altitude change. It causes to change the drag coefficient of the projectile. As the Reynolds number decreases, the skin friction drag increases significantly. It causes to decrease the maximum altitude and the range.