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Synergistic Effect in Combination of Danshen (Salvia miltiorrhiza) Extracts with Antibiotics against Methicillin-resistant Staphylococcus aureus
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  • Synergistic Effect in Combination of Danshen (Salvia miltiorrhiza) Extracts with Antibiotics against Methicillin-resistant Staphylococcus aureus
  • Synergistic Effect in Combination of Danshen (Salvia miltiorrhiza) Extracts with Antibiotics against Methicillin-resistant Staphylococcus aureus
저자명
Cha. Jeong-Dan
간행물명
Food science and biotechnology
권/호정보
2009년|18권 5호|pp.1263-1272 (10 pages)
발행정보
한국식품과학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Danshen (Salvia miltiorrhiza Bunge) is a traditional Korean medicine that is commonly used for the treatment of inflammatory diseases such as edema, arthritis, hepatitis, and endangitis. The several extracts of danshen were tested for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) isolated in clinic by broth microdilution method, the checkerboard, and time-kill methods to evaluate the synergistic effects of the combination of the extracts with antibiotics. The chloroform ($CHCl_3$) and n-hexane (HEX) extracts [minimum inhibitory concentration (MIC), 0.0078-0.3125${mu}g/mL$; minimum bactericidal concentration (MBC), 0.019-0.625${mu}g/mL$] were found to have strong antibacterial activity against MRSA. Additionally, when the $CHCl_3$ and HEX extracts were co-administered with ampicillin or oxacillin, a synergistic effect against MRSA was observed. Furthermore, a time-kill study evaluating the effects of the extracts against MRSA indicated that treatment with the $CHCl_3$ extract in combination with ampicillin or oxacillin produced rapid bactericidal activity. These results suggest that danshen extracts may have potently antimicrobial activity and thus, it can be a suitable phytotherapeutic agent for treating MRSA infections.