Recent earthquake events revealed that severe seismic damages were concentrated mostly at sites composed of soil sediments rather than firm rock. This indicates that the site effects inducing the amplification of earthquake ground motion are associated mainly with the spatial distribution and dynamic properties of the soils overlying bedrock. In this study, an integrated GIS-based information system for geotechnical data was constructed to establish a regional counterplan against ground motions at a representative metropolitan area, Seoul, in Korea. To implement the GIS-based geotechnical information system for the Seoul area, existing geotechnical investigation data were collected in and around the study area and additionally a walkover site survey was carried out to acquire surface geo-knowledge data. For practical application of the geotechnical information system used to estimate the site effects at the area of interest, seismic zoning maps of geotechnical earthquake engineering parameters, such as the depth to bedrock and the site period, were created and presented as regional synthetic strategy for earthquake-induced hazards prediction. In addition, seismic zonation of site classification was also performed to determine the site amplification coefficients for seismic design at any site and administrative sub-unit in the Seoul area. Based on the case study on seismic zonations for Seoul, it was verified that the GIS-based geotechnical information system was very useful for the regional prediction of seismic hazards and also the decision support for seismic hazard mitigation particularly at the metropolitan area.