This paper presents multiple fuzzy prediction systems based on an Interval type-2 TSK fuzzy Logic System so that the uncertainty and the hidden characteristics of nonlinear data can be reflected more effectively to improve prediction quality. In proposed method, multiple fuzzy systems are adopted to handle the nonlinear characteristics of data, and each of multiple system is constructed by using interval type-2 TSK fuzzy logic because it can deal with the uncertainty and the characteristics of data better than type-1 TSK fuzzy logic and other methods. For input of each system, the first-order difference transformation method are used because the difference data generated from it can provide more stable statistical information to each system than the original data. Finally, computer simulations are performed to show the effectiveness of the proposed method for two typical time series examples.