This study was designed to investigate the protective effect of the combination of fucoidan and lutein against AAPH-induced oxidative stress in THP-1 cells. The combination of fucoidan and lutein existed significant antioxidant effect on AAPH-damaged THP-1 cells by using lipid peroxidation and cellular antioxidant capacity assay. Fucoidan($1;{mu}g/m{ell}$) and lutein($10;{mu}g/m{ell}$) did not affect at all the viability of THP-1 cells, but protected the AAPH-damage of THP-1 cells at the same concentration. The viability of THP-1 cells was 0% with 1 mM AAPH alone, the protective effect of fucoidan($1;{mu}g/m{ell}$) and lutein($10;{mu}g/m{ell}$) was 37% and 36%, respectively. The combination of fucoidan($1;{mu}g/m{ell}$) and lutein($10;{mu}g/m{ell}$) exhibited significant inhibitory effect of lipid peroxidation using TBARS assay and cellular antioxidant capacity using DCFH-DA assay. In lipid peroxidation, the TBARS value of 1 mM AAPH alone was $0.8{pm}0.03;nM$ MDA, its of the combination of fucoidan($1;{mu}g/m{ell}$) and lutein($10;{mu}g/m{ell}$) was $0.2{pm}0.05;nM$ MDA. In cellular antioxidant capacity, the combination of fucoidan($1;{mu}g/m{ell}$) and lutein($10;{mu}g/m{ell}$) exhibited significant cellular antioxidant capacity of 76%, whereas quercetin($10;{mu}M$) as positive control exhibited the cellular antioxidant capacity of 32%. These results indicate that the cotreatment of fucoidan and lutein protects against AAPH-induced THP-1 cell damage by inhibiting lipid peroxidation, increasing cellular antioxidant capacity.