This paper as basic work on the regional economic policy of Korean government considers economic conditions and fundamentals of the cold started 5+2 mega-regional economic zones and makes a comparative study of regional economic power of national mega-regional economic zones based on the established economic indicator. Therefore, this study aims to consider henceforward policy direction of the mega-regional economic zone and the validity of the regional economic policy, which promote autonomous mega-regional economic zone in dimension to secure the global competitiveness. According to the comparison result of regional economic power index, the capital area had absolute superiority, while Gangwon, Honam and Jeju areas were relatively weak. Since the given regional conditions are dissimilar, the government must consider regional characteristics and economic fundamentals carefully, as they push henceforth regional development policy for the mega-regional economic zone. What is more, the government should promote a balance of the regional development, through to maintain demand-based policy and demand-pull policy flexibly, which are based on demand analysis, as well as unequal quota budget and policy for regions, which are relatively falling behind in terms of development and income.