The objective of this study was to examine antioxidant and anticytokine effects of bovine colostrum (BC) in an intestinal ischemia/reperfusion injured rat model. Forty Sprague-Dawley rats were induced intestinal ischemia/reperfusion injury. After reperfusion the rats were given BC, 0.9% saline or low fat milk (LFM) orally. The antioxidative activities using superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT), and malondialdehyde (MDA) were analyzed in this study. Serum cytokine levels [tumor necrosis factor (TNF)-${alpha}$, interlukin (IL)-$1{eta}$, IL-6, and IL-10] were also checked. SOD ($1.53{pm}0.23$ U/mg of protein), GSH-PX ($7.62{pm}0.66$ U/mg of protein), and CAT ($42.16{pm}3.16$ U/mg of protein) activities increased and MDA level ($0.58{pm}0.05$ mmol/mg of protein) decreased significantly in rats fed BC compared to rats fed saline or LFM (p<0.05). TNF-$alpha$ ($7.63{pm}1.31$ pg/mL), IL-$1{eta}$ ($49.43{pm}4.43$ pg/mL), and IL-6 ($62.85{pm}7.60$ pg/mL) in rats fed BC were significantly lower than saline or LFM (p<0.005), whereas there was no significant difference in IL-10 ($220.3{pm}22.06$ pg/mL) between experimental groups. In conclusion, BC may have both antioxidative and anticytokine effects in an intestinal ischemia/reperfusion rat model.