Recently, the smart grid has become a hot issue and interest in related power sources have increased accordingly. The implementation of a smart grid can enable many generation resources to be linked to the power system, including small-scale reactors for the purpose of co-generation. Research on small-scale reactors is being carried out all over the world. Similarly, Korea is also conducting research on multi-purpose regional energy systems using nuclear energy. This paper proposes a real-time data acquisition and analysis system for small-scale reactors, and is known as the REX-10 (Regional Energy rX 10 MVA). This analysis requires real-time simulations for the power system since it needs data communication with a remote REX-10. A RTDS (Real Time Digital Simulator) has been used for the simulation, and a SCADA/HMI system interfaced with the RTDS is proposed for the purpose of monitoring and control of the regional energy system.