Purpose: The aim of this study was to investigate the relationship between social support and quality of life (QOL) in elderly people and to examine potential cross-cultural differences. Methods: The author surveyed 82 elderly people, over the age of 65, residing in a nursing home in a Korean rural area and 73 Korean immigrants living in Houston Texas USA who were also elderly. The degree of social support was measured with 20 questions that were answered using a 5 grade scale. The quality of life was measured in 5 fields (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, each scored using a 3 grade scale) with EUROQOL EQ-5D. Results: The mean score of social support was 65.43 for domestic Korean elderly people (range: 26 to 98); it was 73.43 for elderly Korean Americans (range: 26 to 100). The score was lower for domestic Koreans despite the traditional environment (p<0.05). Regarding QOL, 61% of domestic Korean elderly people complained of pain/discomfort and 47.5% appeared to have anxiety/depression, 30.5% complained of limitations in mobility, 20.7% reported limitations in usual activities, and 14.6% had limitations in basic self.care activity such as washing or dressing. A similar proportion of Korean American elderly had limitations in usual activities (19.2%) and self care activity (9.5%). But significantly fewer complained of anxiety/depression (16.5%, p<0.01) or pain/discomfort (38.3%, p<0.01). The major differences in psychological domains of QOL may be related to the degree of social support and the difference in the socio.cultural environment. Conclusion: Social support is a major determinant of QOL, especially for psychological domains, and these relationships are under the influence of the socio.cultural environment.