In this paper, the thickness effect on the wrinkle-crease interaction behavior of corner-loaded creased square membranes was studied using geometrically nonlinear post-buckling analysis. The membranes were modeled using shell elements, and the meshes were seeded with semi-random geometrical imperfection to instigate the buckling deformation. Results indicated that the wrinkle-crease interaction behavior was significantly dependent on the membrane thickness. Both the global and local wrinkles developed earlier as the thickness decreased. It was also found that the wrinkling behavior depended on the initial deployment angle in which the local wrinkle initiation occurred earlier, while the global wrinkle formation was delayed as the angle increased.