A continuing challenge in the aviation industry is how to safely keep aircraft in service longer with limited maintenance budgets. Therefore, all the advanced countries in aircraft technologies put great efforts in prediction of failure rate in parts and system, but in the domestic aircraft industry is lack of theoretical and experimental research. Prediction of failure rate provides a rational basis for design decisions such as the choice of part quality levels and derating factors to be applied. For these reasons, analytic prediction of failure rate is essential process in developing aircraft structure. In this paper, a procedure for prediction of failure rate for aircraft structural parts is presented. Cargo door kinematic parts are taken to illustrate the process, in which the failure rate for Hook part is computed by using Monte Carlo Simulation along with Response Surface Model, and system failure rate is obtained afterwards.