In this paper, a simple approach is presented for studying the dynamic response of multi-span steel bridges supported by pylons of different heights, subjected to earthquake motions acting along the axis of the bridge with spatial variations. The analysis is carried out using the modal analysis technique, while the solution of the integral-differential equations derived is obtained using the successive approximations technique. It was found that the height of piers and the quality of the foundation soil can affect significantly the dynamical behavior of the bridges studied. Illustrative examples are presented to highlight the points of concern and useful conclusions are gathered.