With taking the geometric nonlinearity of bridge structure into account, a framework is presented for predicting the dynamic responses of a long-span suspension bridge subjected to running train and turbulent wind. The nonlinear dynamic equations of the coupled train-bridge-wind system are established, and solved with the Newmark numerical integration and direct interactive method. The corresponding linear and nonlinear processes for solving the system equation are described, and the corresponding computer codes are written. The proposed framework is then applied to a schemed long-span suspension bridge with the main span of 1120 m. The whole histories of the train passing through the bridge under turbulent wind are simulated, and the dynamic responses of the bridge are obtained. The results demonstrate that the geometric nonlinearity does not influence the variation tendency of the bridge displacement histories, but the maximum responses will be changed obviously; the lateral displacement of bridge are more sensitive to the wind than the vertical ones; compared with wind velocity, train speed affects the vertical maximum responses a little more clearly.