Based on the Model Coupled Method (MCM), a case study has been carried out on a Concrete-Filled Steel Tubular (CFST) tied arch bridge to investigate the vibration problem. The mathematical model assumed a finite element representation of the bridge together with beam, shell, and link elements, and the vehicle simulation employed a three dimensional linear vehicle model with seven independent degrees-of-freedom. A well-known power spectral density of road pavement profiles defined the road surface roughness for Perfect, Good and Poor roads respectively. In virtue of a home-code program, the dynamic interaction between the bridge and vehicle model was simulated, and the dynamic amplification factors were computed for displacement and internal force. The impact effects of the vehicle on different bridge members and the influencing factors were studied. Meanwhile the acceleration responses of some of the components were analyzed in the frequency domain. From the results some valuable conclusions have been drawn.