The aim of this work is to analyse and discuss the use of the Economic Evaluation and of some new "metrics" for an appropriate valuation of membrane operations in the logic of Process Intensification. In particular, the proposed approach has the goal to show how the utilized indicators can drive to the choice of the most convenient process. Although in this work the planned procedure is applied, as a case study, to the membrane-based systems for boron and arsenic removal from waters, the suggested approach can be generally applied to any other process of interest.