Indonesia is well-known as biggest producer of seaweed especially for Eucheuma and Gracilaria and also has huge potential resources and capability to develop seaweed cultivation and product. There are several provinces which have potential resources and have been contributing on seaweed production. The next challenge about seaweed production is using integrated system on brackishwater and marine aquaculture. Furthermore, about 2,000,000 ton of potential seaweed production is not explored yet. This article also tries to figure out some related aspects which are technical, economical and forecasting aspect. There is a disease which named "ice-ice" is one of the main problem and giving a new challenge in developing of problem solving for seaweed cultivation method. Economical parameters are also main important key to find out the feasibility of seaweed cultivation industry. In addition, the seaweed cultivation and production in Indonesia also have potential performance on biofuel resources as a part for solving the world problem on energy demand.