The development of modern civilization result from the abundance of material. Yet modern people live with chronic mild stress. Excessive chronic mild stress leads to various diseases. From the risk of the disease in order to protect our bodies need to manage chronic mild stress. The purpose of this study is to inspection the effectiveness of detecting in chronic mild stress using the Multi-sensor system. The Multi-sensor system is designed that can be measure three kinds of vital signals of chronic mild stress for the detection. First Photoplethysmogram(PPG), second Electro Dermal Activity(EDA), third Skin Temperature(SKT). The ages and occupations exposed to chronic mild stress, people often use out of this system was applied to dairy products(Pen). In addition, vital signals that occur when the variety of noise was used to remove the accelerometer. Chronic mild stress by the analysis of measured vital signals from Multi-sensor system to the measurement information to a PC to a wireless transmission(Bluetooth). In this study, using Multi-sensor system writing conditions and a variety of situations in the movement to measure vital signals and measurement results verified the accuracy and reliability. Through this measure chronic mild stress in everyday life and managing to maintain will help more healthy lifestyle.