The kill probability of a missile depends on guidance error, warhead performance, and etc. In this paper, we analyzed the kill probability of anti-tank missile in a new approach. Under the condition that the missile hit the target, we studied the effect of angle of attack and impact angle. High impact angle increase the probability that the missile hits the upper armour which is relatively weaker, while high angle of attack at the impact instant decreases the effectiveness of the jet induced by the warhead. We proposed a way to increase the capability of penetration by analyzing the interrelation between impact angle and angle of attack.