Inconel 718 alloy has been applied to high temperature, high load and corrosion resistant environments due to its superior properties. However, This alloy is a difficult-to-cut nickel-based superalloy and the chipping or notch wear is mainly generated on the cutting edge of the tool. In this study, the machinability of Inconel 718 is investigated to improve tool life under various cutting conditions with TiCN-based coated ball-end mills. The cutting conditions can be suggested to improve both the tool life and machined surface quality in Inconel 718 high speed machining.