One of methods that accomplish fuel-efficient vehicle is to reduce the overall vehicle weight by using aluminum structure typically for cross members, rails and panels in body and chassis. For aluminum structures, the use of Self Piercing Rivet(SPR) is a relatively new joining technique in automotive manufacture. To predict SPR fatigue life, fatigue behavior of SPR connections needs to be investigated experimentally and numerically. Tests and simulations on lap-shear specimen with various material combinations are performed to obtain the joining strength and the fatigue life of SPR connections. A Finite element model of the SPR specimen is developed by using a FEMFAT SPR pre-processor. The fatigue lives of SPR specimens with the curvature are predicted using a FEMFAT 4.4e based on the liner finite element analysis.