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Cytotec Induced Embryotoxicity in Developing Mus musculus
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  • Cytotec Induced Embryotoxicity in Developing Mus musculus
  • Cytotec Induced Embryotoxicity in Developing Mus musculus
저자명
Naeem. Khadija,Ahmad. Naveed,Asmatullah. Asmatullah
간행물명
Asian-Australasian journal of animal sciences
권/호정보
2010년|23권 10호|pp.1282-1290 (9 pages)
발행정보
아세아태평양축산학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The study was carried out to assess the developmental abnormalities induced by Cytotec in mice during intrauterine life. Pregnant mice were exposed to a single dose of 0, 0.02, 0.04, 0.06, 0.08 and $0.1{mu}g$/g BW on day 8 of gestation. Fetuses were recovered on day 18 of gestation. These fetuses were subjected to morphological and morphometric studies. Morphological studies showed abnormalities like anophthalmia, microophthalmia, micromelia and syndactyly. In addition to these, resorptions were also encountered in the higher dose groups. Morphometric analysis showed an overall reduction in body weight, crown rump length, brain and eye circumference, pinna and snout size, length of fore and hind limb and tail size with a significant difference (p<0.001) compared to controls. The outcomes of histological studies revealed some brain defects like hydrocephaly, enlarged third ventricle and undifferentiated ectoneural cells and abnormalities of the heart included right auricle thrombosis and degeneration of trabecular zone.