Objectives: Analysis and understanding on the health trend of college and university students are paramount to creating healthy campus communities. We evaluated the change of health status, health behavior, and influencing factors among them in the last ten years. Methods: Using the results of the ACHA-National College Health Assessment from 2000 to 2009, we reanalyzed the trend of health condition, health behavior, and health risk factors in linear regression model. Results: In general health of college and university students, major health problem were allergy problems, back pain, and sinus infection. Academic impacts were stress, sleep difficulties, cold/flu, concern for troubled friend or family member, relationship difficulty, and internet use or computer games. Although regular exercise was decreasing among them, it were more likely to have never smoking, no sexual partner, and eating of fruits/vegetables as time passed (p<0.05, p<0.01). Obesity and sleeping difficulty were increasing, while it were less likely to have feeling very sad, feeling hopelessness, and considering attempting suicide (p<0.05, p<0.01). Conclusion: These data expand the understanding of the health needs and capacities among young adults. For Korean college and university students, it is necessary to standardize the data-collection survey to set the college health and healthy campus.