Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones

Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones
Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones

ㆍ 저자명: Kwak. Jae-Hwan,NamGoong. Kwon,Jung. Jae-Kyung,Han. Sang-Bae,Cho. Jung-Sook,Kim. Hwan-Mook,Park. Song-Gyu,Lee. Ki-Ho,Kang. Jong-S
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2010년|33권 5호|pp.663-667 (5 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

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서지반출

기타언어초록

A series of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones (4a-f) was synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, SNB19, A549, MCF7 and MCF7/ADR). They all appeared to be less potent than doxorubicin against all doxorubicin sensitive human cancer cell lines tested. However, these compounds retained considerable cytotoxic activity against the doxorubicinresistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. The most active compound 4c was equipotent with doxorubicin against HCT15 cell line.

키워드

Cytotoxic activity Diazacyclopenta[b]anthracene-5 10-diones

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