Objectives: The objective of this study was to compare the effects of Sweet Bee Venom(Sweet BV) Therapy between the hand paresthesia patients with Osteoporosis and without Osteoporosis. Methods: This study was carried out to established the clinical criteria of hand parethesia. The patients who had past history of diabeics, neuropathy induced by alcohol or drug and was positive on Myofacial Pain Syndrome Theory were excluded. 32 patients who had hand paresthesia related with unknown-reason was selected by the interview process. And the effects of treatment were analyzed using VAS score before treatment, after treatment, after 1 month and after 3 months. Results and conclusion: After treatment, While Osteoporosis group decrease from $64.81{pm}7.81$ to $27.21{pm}7.32$, Non-Osteoporosis group decrease from $58.76{pm}1.43$ to $24.74{pm}3.81$ by VAS scores. and After 3 months, While Osteoporosis group increase from $27.21{pm}7.32$ to $54.96{pm}9.40$, Non Osteoporosis group increase from $24.74{pm}3.81$ to $32.43{pm}5.57$. Non-Osteoporosis group was accordingly more effective than Osteoporosis group after 3 months. So Sweet BV therapy for hand numbness patients without Osteoporosis was e effective than patients with Osteoporosis.