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Spirulina maxima 초고압 추출물의 피부 면역 활성 증진
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  • Spirulina maxima 초고압 추출물의 피부 면역 활성 증진
저자명
오성호,강도형,최운용,서용창,허수진,정경환,이현용,Oh. Sung-Ho,Kang. Do-Hyung,Choi. Woon-Yong,Seo. Yong-Chang,Heo. Soo-Jin,Jeong. Kyung-Hwan,Lee. Hyeon
간행물명
Ocean and polar research
권/호정보
2010년|32권 2호|pp.157-164 (8 pages)
발행정보
한국해양연구원
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

A marine alga, Spirulina maxima, was extracted under high pressure and low temperature conditions at 500 MPa and $60^{circ}C$ for 5 and 10 min. A high pressure of 500 MPa was applied to improve process yields because of low temperature extraction. This method resulted in highest higher extraction yield of 26.1% (w/w) in comparison to those results obtained from conventional extraction methods which produced a yield of 17.6% (w/w) from water. The extracts from this process also showed 19% of low cytotoxicity against human normal fibroblast cells in adding 1.0 mg/ml of the highest concentration. The crude extract significantly reduced the production of Prostaglandin $E_2$ ($PGE_2$) from CCD-986sk cells and increased nitric oxide production by macrophages. These higher activities of enhancing skin immune functions were found to have high antioxidant extract properties, like a 98% increase in DPPH radical scavenging activity. The extracts from the high pressure process showed a higher elution of active components than other processes and generated new compounds based on HPLC analysis. This clearly indicates that the extracts from high pressure and low temperature conditions have higher skin immune activation properties that have not been previously reported.