Synthesis and Antitumor Screening of New 1,7-Diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-${alpha}$]pyrimidin-5(1H)-ones

Synthesis and Antitumor Screening of New 1,7-Diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-${alpha}$]pyrimidin-5(1H)-ones
Synthesis and Antitumor Screening of New 1,7-Diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-${alpha}$]pyrimidin-5(1H)-ones

ㆍ 저자명: Shawali. Ahmad S.,Sherif. Sherif M.,Darwish. Manal A. A.,El-merzabani. Mahmoud M.
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2010년|33권 1호|pp.55-60 (6 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

A new series of 3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-1,7-diphenyl-[1,2,4]triazolo[4,3-${alpha}$]pyrimidin-5(1H)-ones 4 was prepared by reaction of the enaminone 2 with hydrazonoyl halides 3. The preliminary screening for antitumor activity of the synthesized compounds was carried out against Ehrlich Ascites Carcinoma tumor cells. The results revealed that the studied compounds 4 have low or no antitumor activity towards EAC tumor cells.

키워드

Enaminone Hydrazonoyl halides Pyrazole [1 2 4]Triazolo[4 3-${alpha}$]pyrimidine

다운URL