The new concept micro devices consisting of various biomolecules have been developed in clinical, pharmaceutical, and environmental fields. Particularly, various diagnostics using biomolecule related device have been investigated and commercialized to detect specific molecules in complex matrix. In recent days, biomolecules have been employed to electronic device to generate new alternatives of silicon based nano electronics by applying natural behaviors of biomolecules. We reviewed here the bioelectronic device consisting of proteins developed by mimicking natural phenomena. We surveyed the working principle, fabrication technologies, and memory function validation of metallo-protein based biomemory device.