기관회원 [로그인]
소속기관에서 받은 아이디, 비밀번호를 입력해 주세요.
개인회원 [로그인]

비회원 구매시 입력하신 핸드폰번호를 입력해 주세요.
본인 인증 후 구매내역을 확인하실 수 있습니다.

회원가입
서지반출
Enhancement of Organ Regeneration in Animal Models by a Stem Cell-Stimulating Plant Mixture
[STEP1]서지반출 형식 선택
파일형식
@
서지도구
SNS
기타
[STEP2]서지반출 정보 선택
  • 제목
  • URL
돌아가기
확인
취소
  • Enhancement of Organ Regeneration in Animal Models by a Stem Cell-Stimulating Plant Mixture
  • Enhancement of Organ Regeneration in Animal Models by a Stem Cell-Stimulating Plant Mixture
저자명
Kiss. Istvan,Tibold. Antal,Halmosi. Robert,Bartha. Eva,Koltai. Katalin,Orsos. Zsuzsanna,Bujdoso. Laszlo,Ember. Istvan
간행물명
Journal of medicinal food
권/호정보
2010년|13권 3호|pp.599-604 (6 pages)
발행정보
한국식품영양과학회
파일정보
정기간행물|ENG|
PDF텍스트
주제분야
기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Adult stem cells play an important role in the regeneration of damaged organs. Attempts have already been made to enhance stem cell production by cytokines, in order to increase the improvement of cardiac functions after myocardial infarction. In our present study we investigated the possibility whether instead of cytokine injection dietary stimulation of stem cell production accelerates the organ regeneration in animals. A dietary supplement, Olimpiq$^{(R)}$ StemXCell (Crysta Institute Ltd., Eger, Hungary), containing plant extracts (previously proved to increase the number of circulating $CD34^+$ cells) was consumed in human equivalent doses by the experimental animals. In the first experiment carbon tetrachloride was applied to CBA/Ca mice, to induce liver damage, and liver weights between StemXCell-fed and control animals were compared 10 days after the treatment. In the second model experimental diabetes was induced in F344 rats by alloxan. Blood sugar levels were measured for 5 weeks in the control and StemXCell-fed groups. The third part of the study investigated the effect of StemXCell on cardiac functions. Eight weeks after causing a myocardial infarction in Wistar rats by isoproterenol, left ventricular ejection fraction was determined as a functional parameter of myocardial regeneration. In all three animal models StemXCell consumption statistically significantly improved the organ regeneration (relative liver weights, $4.78{pm}0.06;g$/100 g vs. $4.97{pm}0.07;g$/100 g; blood sugar levels at week 5, $16{pm}1.30;mmol/L$ vs. $10.2{pm}0.92;mmol/L$; ejection fraction $57.5{pm}2.23$ vs. $68.2{pm}4.94$; controls vs. treated animals, respectively). Our study confirms the hypothesis that dietary enhancement of stem cell production may protect against organ injuries and helps in the regeneration.