The influence of structural configuration on vibration responses of smart laminated beams under random loading is studied. The effect of laminate configurations and locations of sensors/actuators in the smart system is also investigated. The layer-wise approximation for displacement and electric potential is utilized to construct the finite element model. The closed-loop control response is determined through an optimal control algorithm based on the Linear Quadratic Regulator (LQR). The correlation coefficient between the input random force and the applied actuating voltage for various configurations is also computed. It is revealed that for softer configurations, the correlation coefficient is higher than that for harder configurations. The study on the effect of sensor/actuator collocation pairs on optimal vibration control reveals that as the actuator shifts away from the sensor location, the peak of power occurs at higher frequency and becomes more distributed through all the frequencies in the domain.