Purpose: The purpose of this study was to analyze effects of cardiovascular disease prevention in small scale enterprise using community-based approach. Method: The target work site included 4,050 small scale enterprises which were under 50 in non-manufacturing workplace and total 20,986 employees were enrolled. Data collection was conducted from March to December, 2008 by 46 occupational health nurses who were registered in Korean Association of Occupational Health Nurses. Results: The rate of smoking was decreased from 39.9% to 34.6%, and normal BMI group was increased from 61.6% to 64.0%. Evaluation of post-intervention blood pressure(BP) outcomes revealed that significant reductions in systolic BP and diastolic BP(3.25mmHg and 1.89mmHg, respectively) were achieved. In addition, the amount of reduction in total cholesterol level was $180.89{pm}28.22mg/dL$ at pre-ntervention and $177.71{pm}24.73mg/dL$ at post-intervention. Conclusion: Cardiovascular prevention program by community-based approach was an effective strategy for quitting smoking and improving BMI, BP, and cholesterol control.