Issues regarding the design of midcourse guidance laws for antimissiles are addressed. The antimissile is expected to be guided to a place with a desired direction, where a ballistic missile is predicted to pass in the reverse direction, so that the target can be easily found and locked for terminal interception. The predicted location and direction of a ballistic missile may vary with time, due to information update using a trajectory prediction algorithm. To fulfill the guidance performance, the guidance laws are designed by combining the Takagi-Sugeno (T-S) fuzzy approach and the Sliding Mode Control (SMC) technique. Under the designed guidance law, it is shown that the antimissile is able to be efficiently guided to a specified location and direction, even when the existence of uncertainties and disturbances.