Purpose: The purpose of this study was to investigate self-esteem, family function, and social support which might influence stress in college students. Method: Data were collected from October 15 to December 20, 2007 when 411 students completed a questionnaire which included Self-esteem scale, Family APGAR questionnaire, Multidimensional Scale of Perceived Social Support and Global Assessment of Recent Stress scale. The collected data was analyzed with the SPSS Win 14.0 statistics program. Results: The scores for stress showed significantly negative correlations with the scores for self-esteem (r= -.394, p<.001), family function (r= -.215, p<.001), and social support (r= -.249, p<.001). Self-esteem, family function and social support by friends were significant predictors and accounted for 18.5% of the variance in stress in undergraduate students. Conclusion: Future stress management programs for undergraduate students should be developed to reinforce self-esteem, family function and social support by friends.