We report relative proper motion measurements of $H_{2}O$ masers in massive star-forming region W51 Main, based on data sets of VLBI observations for $H_{2}O$ masers at 22 GHz with Japanese VERA telescopes from 2003 to 2006. Data reductions and single-beam imaging analysis are to measure internal kinematics of maser spots and eventually to estimate the three-dimensional kinematics of $H_{2}O$ masers in W51 Main. Average space motions and proper motion measurements of $H_{2}O$ masers are given both graphical and in table formats. We find in this study that W51 Main appears to be associated with hyper-compact H II region with multiple massive proto-stars whose spectral types are of late O.