Objectives: The purpose of this research is to investigate correlationship between Hwa-Byung and various factors, including Sasang Constitution. Methods: The research about Hwa-Byung, various factors and Sasang Constitution were carried out for 649 Participants, male was 272 and female was 377. Hwa-Byung diagnosed by Hwa-Byung Diagnostic Interview Schedule(HBDIS). Sasang Constitution was diagnosed by a Sasang Constitutional specialist with recorded voices, face pictures, tongue pictures and researched data about Sasang Constitution. Collected data were analyzed by the qui-square test and t-test. Results: 1. The prevalence of Hwa-Byung in Taeeumin and Soeumin were higher than that of Soyangin but it was not significant. 2. In the case of meeting frequency of friends, Hwa-Byung group was higher than none Hwa-Byung group and it was significant. 3. In the case of existence of negative influencing people, the rate of Hwa-Byung group was higher than that of none Hwa-Byung group. Among them, Interfere, Blame, Discomfort and Indifferent were significant. Conclusions: Hwa-Byung may have correlationship with Sasang Constitution, meeting frequency of friends and existence of negative influencing people.