Previous studies "Dong-uibogam(東醫寶鑑)" or "Dong-uisusebowon(東醫壽世保元)", Korean medical text written in the 16th/19th century, have focused mainly on his theories of Daoism and Neo-Confucianism or Post-Confucianism. This Study suggests that the "Dong-uibogam" and "Dong-uisusebowon" were the scholarly products of the Early Modern Neo-Confucians during the Joseon Dynasty period. These Early Modern Neo-Confucians ruled the dynasty rationally, and edited books on medical science, one of which were the "Dong-uibogam" or "Dong-uisusebowon". In these books, religious aspects of Daoism was excluded because these elements were not in agreement with medical science or Neo-Confucianism. The "Dong-uibogam" and "Dong-uisusebowon" were also translated into the Korean vernacular script based on an obligation to govern the people. This was example of Confucian enlightenment which was Early Modernity of "Dong-uibogam(東醫寶鑑)" or "Dong-uisusebowon(東醫壽世保元)" thought.