This study presents the pattern and shape generation process using morphogenesis technique. The process consists of three parts: pattern creation module, stiffness optimization module and size optimization module. The pattern creation module generates the various patterns and shapes using cellular automata model of morphogenesis technique, and the stiffness optimization module finds out the structural shape with maximum stiffness by minimizing the compliance subject to the target weight constraints. Also, the size optimization module is performed to obtain the structure with minimum weight subject to the target displacement based on the results of stiffness optimization. From the results through the application example, we can find out the optimal pattern shape and alternative by the selection of reasonable rule pattern. Therefore, the proposed optimal shape generation process using morphogenesis and cellular automata can provide the efficient initial shape design data and evaluate the optimal alternative of structure.