In this study cyclodextrin (CD) has been grafted onto cellulose back-bone of cotton fabric using citric acid as crosslinker. The CD-grafted fabric was characterized by SEM and FTIR analysis. The percent grafting of CD on fabric has been found to increase with concentration of CD, citric acid, and sodium dihydrogen phosphate. The CD-grafted fabric has been loaded with silver(I) ions for the purpose of obtaining a slow release device. The Ag(I) loaded grafted fabric showed fair antibacterial properties against E. Coli. The release of Ag(I) ions from the CD-grafted fabric was observed for a period of seven days.