This study was to examine the neuroticism related to psychological characteristics of each Sasang types using SCL-90-R with 107 students from College of Oriental Medicine, Daeguhaani University. We did ANOVA analysis with seven neuroticism-related sub-scales and found significant differences in somatization (F=3.701, p=0.028) and hostility (F=4.396, p=0.015). The post-hoc analysis showed that the So-Yang type ($23.17{pm}8.95$) has significantly (p=0.048, p=0.012) higher score than Tae-Eum ($19.25{pm}5.97$) and So-Yang($19.25{pm}5.76$) type in somatization. In hostility, the So-yang type ($11.31{pm}3.98$) has significantly (p=0.011, p=0.015) higher score than Tae-Eum ($8.80{pm}2.61$) and So-Eum ($9.44{pm}3.35$) type. The ANOVA analysis with female subjects found significant differences in anxiety (F=3.88, p=0.03) and hostility (F=5.04, p=0.01). The post-hoc analysis showed that the So-Yang type ($20.36{pm}5.44$, $12.36{pm}3.82$) has significantly (p=0.043, p=0.015) higher score compared to the So-Eum type ($15.46{pm}3.36$, $8.69{pm}2.06$) in anxiety and hostility. The profile analysis using seven neuroticism-related subscalesof SCL-90-R did not revealed significant differences (Flatness with Greenhouse-Geisser (F=202.347, p=0.0001), Parallelism with Greenhouse-Geisser (F=1.428, p=0.191)). We discussed the implications of neuroticism in Sasang typology and SCL-90-R somatization, anxiety and hostility scales. This study showed opposite results compared to the previous studies that So-Eum type has higher neuroticism compared to the So-Yang and Tae-Eum type. The reason for this discrepancy between this and previous studies, and differences between male and female should be examined thoroughly with larger and balanced sample.